• Status: Closed

  • Key features: CRACK IT Challenges: a milestone-driven funding competition from The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs).

  • Programme: SBRI

  • Award: Up to £1m

  • Opens: 15 Sep 2014, 00:00

  • Registration closes: 12 Nov 2014, 12:00

  • Closes: 19 Nov 2014, 12:00

  • Support phone number: 0300 321 4357

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NC3Rs logoThe National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is an independent scientific organisation that supports the UK science base through the application of the 3Rs. 
CRACK IT logoCRACK IT Challenges is a challenge-led funding competition from the NC3Rs which is designed to: 
  • fund collaborations between industry, academics and SMEs
  • minimise the use of animals in research
  • support the development of marketable products and/or improved business processes.
This year the Challenges are funded by the NC3Rs with in-kind contributions from the Challenge Sponsors (for example, data, access to compounds and equipment). 
The NC3Rs is launching the 2014 CRACK IT Challenges competition at an event in central London on Friday, 12 September 2014. The launch event provides an opportunity to meet the Challenge sponsors and potential new collaborators. This event is free to attend but registration is essential. The deadline for registration is Friday, 5 September 2014.
There are up to three Challenges this year with a total of seven Sponsors, with funding ranging from £100k to £1m and contracts from 1-3 years:
  • Neuratect: Development of high-throughput in vitro models to better predict CNS safety liabilities (sponsored by GlaxoSmithKline, BASF, Sanofi and Abbvie)
  • Targeting Off-Targets: Off-target chemical-receptor interactions (sponsored by Unilever and Dow Agrosciences)

There is also an additional non SBRI challenge run independently from the SBRI process.  Please register and apply directly from the NC3R's website for this challenge only:

  • QSARs mix (Single Phase): Computer Based Prediction Using Structural Alerts to Assess Toxicity Endpoints (Sponsored by Shell)

Download the briefs 

How to apply

The competition will open on Monday, 15 September 2014, and the deadline for applications is 12.00 noon on Wednesday, 19 November 2014. In order to apply you must register with the SBRI for the competition by 12.00 noon on Wednesday, 12 November 2014.
When you register you will be sent login details for the FTP site where you will be able to download the guidance documents (the documents are available from this page too), you will also be sent an application form with an assigned reference number. You will need this reference number for all subsequent enquiries.
If you wish to submit more than one application to the competition, please contact the SBRI Business Support Group at support@innovateuk.org or 0300 321 4357.
Questions about the application process and SBRI should be directed to the Technology Strategy Board's Business Support Group at support@innovateuk.org or 0300 321 4357. Questions related to the Challenges themselves should be addressed directly to the NC3Rs at crackitenquiries@nc3rs.org.uk or 020 7611 2233
Key dates
  • Open: 15 September 2014
  • Registration close date: 12.00 noon on 12 November 2014
  • Closes: 12.00 noon 19 November 2014

Further information